Search found 3 matches

by Daniel E. Weeks
Fri Aug 14, 2015 5:05 pm
Forum: GenABEL
Topic: polygenic function
Replies: 4
Views: 3668

Re: polygenic function

This was written in June 2013: However the family option in polygenic does not really work and should not be used, if you are trying to get the coefficients of the covariates of a logistic regression you should use poligenic_hglm instead. Is this statement still true? I think it probably is, as if I...
by Daniel E. Weeks
Fri Aug 14, 2015 4:55 pm
Forum: ProbABEL
Topic: palogist & covariates
Replies: 0
Views: 3005

palogist & covariates

We are analyzing some binary traits where we need to adjust for relatedness, but each trait also needs to be adjusted for some relevant covariates. When using a quantitative trait, one runs polygenic to generate the required inverse of the variance/covariance matrix and then uses palinear to analyze...
by Daniel E. Weeks
Tue Feb 07, 2012 10:03 pm
Forum: GenABEL
Topic: GWAS case-control with related individuals
Replies: 8
Views: 6453

Re: GWAS case-control with related individuals

Dear Yurii and colleagues, We would like to use GenABEL to test for association for a binary trait while taking family structure into account. From, the posting above, it sounds as if the best way to get the correct p-values would be to first analyze our binary trait using 'polygenic' of GenABEL, an...

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