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This was written in June 2013: However the family option in polygenic does not really work and should not be used, if you are trying to get the coefficients of the covariates of a logistic regression you should use poligenic_hglm instead. Is this statement still true? I think it probably is, as if I...
We are analyzing some binary traits where we need to adjust for relatedness, but each trait also needs to be adjusted for some relevant covariates. When using a quantitative trait, one runs polygenic to generate the required inverse of the variance/covariance matrix and then uses palinear to analyze...
- Tue Feb 07, 2012 10:03 pm
- Forum: GenABEL
- Topic: GWAS case-control with related individuals
- Replies: 8
- Views: 6453
Dear Yurii and colleagues, We would like to use GenABEL to test for association for a binary trait while taking family structure into account. From, the posting above, it sounds as if the best way to get the correct p-values would be to first analyze our binary trait using 'polygenic' of GenABEL, an...